If your prospect is just trying to rank for different keywords, I have some input from personal experience:
With the newest Panda updates, I believe it's easier to rank for keywords that do not match the top-level-domain. This is because Google wants to discourage spammy 3-page websites that just have a really long and targeted url. Many of these sites do not really help the visitor answer his or her question, but instead are just Adsense wheels with freelance content and landing pages optimized for someone to click Adsense inks.
What I'm getting at with all of this, is that your prospect can do SEO for the same domain, using different keywords, as long as the content is really relevant. IMHO, this is the best long-term solution, rather than relying on loopholes in Google's algorithm, which they are constantly trying to close.
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